AFN-001036-01 · EGFR L858R/T790M
Pending reviewCRV-2026-00407-016 · v1 · auto-fitPlates PL-2026-0407, PL-2026-0408 (n = 2 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 2 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0407
- Rep. 2 · PL-0408
- Masked
- IC50 95 % CI
Concentrations: 10-point, 1:3, 0.508 nM – 10.0 µMPoints used 20 / 20
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 100.7 % | [99.4, 102.0] % | Free |
| Bottom | 6.3 % | [5.0, 7.5] % | Free |
| IC50 | 83.5 nM | [78.4, 88.9] nM | Free |
| pIC50 | 7.08 | ± 0.01 (SE) | Derived |
| Hill slope (nH) | 1.18 | [1.10, 1.26] | Free |
R² 0.999RMSE 1.1 %df 16Fit engine 1.2.0 · 20 / 20 points
Review decision
IC50
83.5 nM
95 % CI 78.4–88.9 nM · pIC50 7.08
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 20 / 20 points · no flags