AFN-000196-01 · EGFR WT
RejectedCRV-2026-00440-016 · v1 · auto-fitPlates PL-2026-0440, PL-2026-0441 (n = 2 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 6 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0440
- Rep. 2 · PL-0441
- Masked
- IC50 95 % CI
Concentrations: 10-point, 1:3, 0.508 nM – 10.0 µMPoints used 20 / 20
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 98.7 % | [92.4, 105.1] % | Free |
| Bottom | 5.7 % | [4.6, 6.9] % | Free |
| IC50 | 2.07 µM | [1.78, 2.39] µM | Free |
| pIC50 | 5.69 | ± 0.03 (SE) | Derived |
| Hill slope (nH) | 1.37 | [1.18, 1.56] | Free |
R² 0.997RMSE 1.6 %df 16Fit engine 1.2.0 · 20 / 20 points
Review decision
IC50
2.07 µM
95 % CI 1.78–2.39 µM · pIC50 5.69
Rejected: Compound precipitated at the top two concentrations
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 20 / 20 points · incompleteTop
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Compound precipitated at the top two concentrations” · v1 · auto-fit