AFN-002368-01 · EGFR WT
RejectedCRV-2026-00458-001 · v1 · auto-fitPlates PL-2026-0458, PL-2026-0459 (n = 2 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 9 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0458
- Rep. 2 · PL-0459
- Masked
- IC50 95 % CI
Concentrations: 10-point, 1:3, 0.508 nM – 10.0 µMPoints used 20 / 20
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 113.0 % | [89.9, 136.2] % | Free |
| Bottom | −1.8 % | [−3.6, −0.1] % | Free |
| IC50 | 3.44 µM | [2.10, 5.65] µM | Free |
| pIC50 | 5.46 | ± 0.10 (SE) | Derived |
| Hill slope (nH) | 0.96 | [0.75, 1.17] | Free |
R² 0.994RMSE 2.1 %df 16Fit engine 1.2.0 · 20 / 20 points
Review decision
IC50
3.44 µM
95 % CI 2.10–5.65 µM · pIC50 5.46
Rejected: Compound precipitated at the top two concentrations
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 20 / 20 points · incompleteTop
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Compound precipitated at the top two concentrations” · v1 · auto-fit