AFN-000816-01 · H1975 cells
Approved · lockedCRV-2026-00487-006 · v1 · auto-fitPlates PL-2026-0487 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 4 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0487
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 100.3 % | [81.5, 119.1] % | Free |
| Bottom | 5.8 % | [−0.2, 11.7] % | Free |
| IC50 | 1.18 µM | [0.710, 1.97] µM | Free |
| pIC50 | 5.93 | ± 0.08 (SE) | Derived |
| Hill slope (nH) | 1.13 | [0.60, 1.66] | Free |
R² 0.995RMSE 2.3 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
1.18 µM
95 % CI 0.710–1.97 µM · pIC50 5.93
Electronically signed
mlaurent (mlaurent)
2026-11-04 17:40:00 UTC
Meaning: Approved — result valid for SAR use
record sha256 1ee9…db7d
This result is immutable. A correction creates a new version with a mandatory reason and its own signature.
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · no flags
- Re-authenticatedmlaurent · 2026-11-04 17:40:00 UTCPassword verified for signing
- Signed — Approvedmlaurent · 2026-11-04 17:40:00 UTCMeaning: Approved — result valid for SAR use · v1 · auto-fit · record hash sha256 1ee9…db7d