AFN-001559-01 · H1975 cells
RejectedCRV-2026-00497-006 · v1 · auto-fitPlates PL-2026-0497 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 4 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0497
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 100.3 % | [94.7, 106.0] % | Free |
| Bottom | 7.8 % | [0.4, 15.3] % | Free |
| IC50 | 143 nM | [108, 189] nM | Free |
| pIC50 | 6.84 | ± 0.04 (SE) | Derived |
| Hill slope (nH) | 0.94 | [0.68, 1.19] | Free |
R² 0.998RMSE 1.4 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
143 nM
95 % CI 108–189 nM · pIC50 6.84
Rejected: Curve does not plateau — retest over a wider range
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · no flags
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Curve does not plateau — retest over a wider range” · v1 · auto-fit