AFN-001939-01 · H1975 cells
RejectedCRV-2026-00503-007 · v1 · auto-fitPlates PL-2026-0503 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 3 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0503
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 100.8 % | [98.1, 103.5] % | Free |
| Bottom | 2.1 % | [−6.2, 10.5] % | Free |
| IC50 | 45.3 nM | [35.8, 57.4] nM | Free |
| pIC50 | 7.34 | ± 0.04 (SE) | Derived |
| Hill slope (nH) | 0.94 | [0.77, 1.11] | Free |
R² 0.999RMSE 0.8 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
45.3 nM
95 % CI 35.8–57.4 nM · pIC50 7.34
Rejected: Compound precipitated at the top two concentrations
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · incompleteBottom
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Compound precipitated at the top two concentrations” · v1 · auto-fit