AFN-002248-01 · H1975 cells
RejectedCRV-2026-00509-004 · v1 · auto-fitPlates PL-2026-0509 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 8 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0509
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 97.2 % | [85.0, 109.4] % | Free |
| Bottom | 5.4 % | [2.2, 8.6] % | Free |
| IC50 | 1.67 µM | [1.23, 2.26] µM | Free |
| pIC50 | 5.78 | ± 0.05 (SE) | Derived |
| Hill slope (nH) | 1.31 | [0.91, 1.70] | Free |
R² 0.998RMSE 1.4 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
1.67 µM
95 % CI 1.23–2.26 µM · pIC50 5.78
Rejected: Compound precipitated at the top two concentrations
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · no flags
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Compound precipitated at the top two concentrations” · v1 · auto-fit