AFN-002631-01 · H1975 cells
RejectedCRV-2026-00515-008 · v1 · auto-fitPlates PL-2026-0515 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 10 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0515
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 97.7 % | [87.7, 107.8] % | Free |
| Bottom | 0.8 % | [−2.0, 3.7] % | Free |
| IC50 | 1.47 µM | [1.15, 1.88] µM | Free |
| pIC50 | 5.83 | ± 0.04 (SE) | Derived |
| Hill slope (nH) | 1.27 | [0.96, 1.58] | Free |
R² 0.999RMSE 1.2 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
1.47 µM
95 % CI 1.15–1.88 µM · pIC50 5.83
Rejected: Curve does not plateau — retest over a wider range
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · no flags
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Curve does not plateau — retest over a wider range” · v1 · auto-fit