AFN-002743-01 · H1975 cells
RejectedCRV-2026-00517-004 · v1 · auto-fitPlates PL-2026-0517 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 2 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0517
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 100.9 % | [90.8, 111.0] % | Free |
| Bottom | 3.2 % | [0.5, 5.8] % | Free |
| IC50 | 1.48 µM | [1.15, 1.91] µM | Free |
| pIC50 | 5.83 | ± 0.04 (SE) | Derived |
| Hill slope (nH) | 1.14 | [0.89, 1.39] | Free |
R² 0.999RMSE 1.1 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
1.48 µM
95 % CI 1.15–1.91 µM · pIC50 5.83
Rejected: Curve does not plateau — retest over a wider range
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · incompleteTop
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Curve does not plateau — retest over a wider range” · v1 · auto-fit