AFN-003465-01 · H1975 cells
RejectedCRV-2026-00529-008 · v1 · auto-fitPlates PL-2026-0529 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 2 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0529
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 99.9 % | [75.6, 124.1] % | Free |
| Bottom | −2.4 % | [−10.2, 5.4] % | Free |
| IC50 | 1.17 µM | [0.637, 2.14] µM | Free |
| pIC50 | 5.93 | ± 0.09 (SE) | Derived |
| Hill slope (nH) | 1.15 | [0.50, 1.80] | Free |
R² 0.993RMSE 3.0 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
1.17 µM
95 % CI 0.637–2.14 µM · pIC50 5.93
Rejected: Signal drift across the plate, replicates disagree
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · no flags
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Signal drift across the plate, replicates disagree” · v1 · auto-fit