AFN-003555-01 · H1975 cells
Approved · lockedCRV-2026-00532-004 · v1 · auto-fitPlates PL-2026-0532 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 2 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0532
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 104.8 % | [73.8, 135.8] % | Free |
| Bottom | 5.9 % | [3.2, 8.6] % | Free |
| IC50 | 3.94 µM | [2.07, 7.50] µM | Free |
| pIC50 | 5.40 | ± 0.10 (SE) | Derived |
| Hill slope (nH) | 1.16 | [0.73, 1.60] | Free |
R² 0.998RMSE 1.2 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
3.94 µM
95 % CI 2.07–7.50 µM · pIC50 5.40
Electronically signed
mlaurent (mlaurent)
2026-11-04 17:40:00 UTC
Meaning: Approved — result valid for SAR use
record sha256 489a…d638
This result is immutable. A correction creates a new version with a mandatory reason and its own signature.
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · incompleteTop
- Re-authenticatedmlaurent · 2026-11-04 17:40:00 UTCPassword verified for signing
- Signed — Approvedmlaurent · 2026-11-04 17:40:00 UTCMeaning: Approved — result valid for SAR use · v1 · auto-fit · record hash sha256 489a…d638