AFN-003951-01 · H1975 cells
RejectedCRV-2026-00539-001 · v1 · auto-fitPlates PL-2026-0539 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 5 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0539
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 99.9 % | [64.7, 135.1] % | Free |
| Bottom | −1.2 % | [−6.0, 3.7] % | Free |
| IC50 | 2.66 µM | [1.20, 5.92] µM | Free |
| pIC50 | 5.57 | ± 0.12 (SE) | Derived |
| Hill slope (nH) | 1.09 | [0.53, 1.64] | Free |
R² 0.995RMSE 2.0 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
2.66 µM
95 % CI 1.20–5.92 µM · pIC50 5.57
Rejected: Compound precipitated at the top two concentrations
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · incompleteTop
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Compound precipitated at the top two concentrations” · v1 · auto-fit