AFN-004088-01 · H1975 cells
RejectedCRV-2026-00541-006 · v1 · auto-fitPlates PL-2026-0541 (n = 1 replicates)4PL · Levenberg–Marquardt · unweighted, log₁₀[C]
Curve 6 / 10 in batch
Response vs concentration
- Rep. 1 · PL-0541
- Masked
- IC50 95 % CI
Concentrations: 8-point, 1:3, 4.57 nM – 10.0 µMPoints used 8 / 8
Fit parameters — v1 · auto-fit
y = Bottom + (Top − Bottom) / (1 + 10^((log IC50 − x) · nH))| Parameter | Estimate | 95 % CI | Constraint |
|---|---|---|---|
| Top | 105.4 % | [71.0, 139.7] % | Free |
| Bottom | 6.2 % | [3.7, 8.7] % | Free |
| IC50 | 4.51 µM | [2.33, 8.75] µM | Free |
| pIC50 | 5.35 | ± 0.10 (SE) | Derived |
| Hill slope (nH) | 1.25 | [0.76, 1.74] | Free |
R² 0.998RMSE 1.2 %df 4Fit engine 1.2.0 · 8 / 8 points
Review decision
IC50
4.51 µM
95 % CI 2.33–8.75 µM · pIC50 5.35
Rejected: Curve does not plateau — retest over a wider range
History
append-only- v1 auto-fit createdsystem · 2026-11-04 17:05:40 UTCFit engine 1.2.0 · 8 / 8 points · incompleteTop
- Rejectedmlaurent · 2026-11-04 18:10:00 UTC“Curve does not plateau — retest over a wider range” · v1 · auto-fit